Defects in the interferon‐γ and interleukin‐12 pathways
Identifieur interne : 008441 ( Main/Exploration ); précédent : 008440; suivant : 008442Defects in the interferon‐γ and interleukin‐12 pathways
Auteurs : Sergio D. Rosenzweig [Argentine] ; Steven M. Holland [États-Unis]Source :
- Immunological Reviews [ 0105-2896 ] ; 2005-02.
Abstract
Summary: The interferon‐γ (IFN‐γ)/interleukin‐12 (IL‐12) pathway is a pivotal player in the immune system and is central to controlling mycobacterial infections. We highlight the most recent and relevant advances in understanding this pathway and their repercussions on basic and clinical science. Human mutations in IFN‐γ receptor‐1 (IFN‐γR1), IFN‐γR2, IL‐12p40, IL‐12 receptor‐β1, signal transducer and activator of transcription‐1, and nuclear factor‐κB essential modulator are analyzed in the context of genetic susceptibility to mycobacterial diseases. A diagnostic and therapeutic approach is described. The IFN‐γ/IL‐12 pathway is central in immune control of both environmental and autochthonous challenges, as reflected in human mutations and animal models. Besides being crucial for mycobacterial control, the IFN‐γ/IL‐12 pathway is also involved in the pathogenesis of autoimmune disease as well as tumor development and control. Genotype–phenotype correlations have been established for certain genes in this pathway, some of which have therapeutic implications.
Url:
DOI: 10.1111/j.0105-2896.2005.00227.x
Affiliations:
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Rosenzweig</name><affiliation wicri:level="1"><country xml:lang="fr">Argentine</country><wicri:regionArea>Division of Immunology, Department of Pediatrics, Hospital Nacional de Pediatría Juan P. Garrahan, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M." last="Holland">Steven M. Holland</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, DHHS, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Immunological Reviews</title><title level="j" type="alt">IMMUNOLOGICAL REVIEWS</title><idno type="ISSN">0105-2896</idno><idno type="eISSN">1600-065X</idno><imprint><biblScope unit="vol">203</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="38">38</biblScope><biblScope unit="page" to="47">47</biblScope><biblScope unit="page-count">10</biblScope><publisher>Munksgaard International Publishers</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-02">2005-02</date></imprint><idno type="ISSN">0105-2896</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0105-2896</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Summary: The interferon‐γ (IFN‐γ)/interleukin‐12 (IL‐12) pathway is a pivotal player in the immune system and is central to controlling mycobacterial infections. We highlight the most recent and relevant advances in understanding this pathway and their repercussions on basic and clinical science. Human mutations in IFN‐γ receptor‐1 (IFN‐γR1), IFN‐γR2, IL‐12p40, IL‐12 receptor‐β1, signal transducer and activator of transcription‐1, and nuclear factor‐κB essential modulator are analyzed in the context of genetic susceptibility to mycobacterial diseases. A diagnostic and therapeutic approach is described. The IFN‐γ/IL‐12 pathway is central in immune control of both environmental and autochthonous challenges, as reflected in human mutations and animal models. Besides being crucial for mycobacterial control, the IFN‐γ/IL‐12 pathway is also involved in the pathogenesis of autoimmune disease as well as tumor development and control. Genotype–phenotype correlations have been established for certain genes in this pathway, some of which have therapeutic implications.</div></front></TEI><affiliations><list><country><li>Argentine</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="Argentine"><noRegion><name sortKey="Rosenzweig, Sergio D" sort="Rosenzweig, Sergio D" uniqKey="Rosenzweig S" first="Sergio D." last="Rosenzweig">Sergio D. Rosenzweig</name></noRegion></country><country name="États-Unis"><region name="Maryland"><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M." last="Holland">Steven M. Holland</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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